@article{jbph2026_alifariki48,
  author    = {La Ode Alifariki and Dewi Nopiska Lilis},
  title     = {Anredera cordifolia (Binahong) in Hypertension Management: Phytochemical Basis, Cardiovascular Mechanisms, and Current Evidence},
  journal   = {Journal of Biosciences and Public Health},
  year      = {2026},
  volume    = {2},
  number    = {4},
  pages     = {293-312},
  doi       = {10.5455/JBPH.2026.14},
  issn      = {3104-8749},
  publisher = {4Green Research Society},
  language  = {English},
  keywords  = {Anredera cordifolia; Binahong; Hypertension; Herbal Medicine; Blood pressure;
Endothelial function; Phytochemicals},
  abstract  = {Background: Hypertension remains one of the leading global public health challenges and a major contributor to cardiovascular morbidity and mortality. Despite the availability of effective pharmacological therapies, blood pressure control remains suboptimal in many populations, leading to growing interest in complementary and herbal approaches. Anredera cordifolia (Binahong) is traditionally used for various health conditions and has attracted attention for its potential cardiovascular benefits. Objective: Aimed to synthesize and critically evaluate current evidence regarding the potential role of Binahong leaf decoction in hypertension management, with emphasis on its phytochemical characteristics, biological mechanisms, safety profile, and implications for clinical practice. Methods: A narrative review was conducted using literature retrieved from PubMed, Scopus, Web of Science, ScienceDirect, and Google Scholar. A total of 11 studies were included in the final synthesis, comprising phytochemical investigations, antioxidant studies, mechanistic pharmacological studies, animal experiments, and comparative clinical studies involving herbal antihypertensive interventions. Results: Evidence indicates that A. cordifolia contains bioactive compounds, including flavonoids, polyphenols, saponins, alkaloids, and terpenoids, with antioxidant and vasoprotective properties. Experimental studies suggest potential antihypertensive effects through antioxidant activity, endothelial protection, vasodilation, and moderate angiotensin-converting enzyme inhibition. However, direct clinical evidence remains scarce, with available human studies limited by small sample sizes, methodological heterogeneity, and non-randomized designs. Current data are therefore insufficient to establish clinical efficacy or standardized therapeutic protocols. Conclusions: Anredera cordifolia demonstrates mechanisms that may support blood pressure regulation and cardiovascular protection. Well-designed experimental studies and randomized controlled trials are required to determine its effectiveness, safety, optimal dosage, and potential role in integrative hypertension care.},
  url       = {https://www.jbph.org/article/details/anredera-cordifolia-binahong-in-hypertension-management-phytochemical-basis-cardiovascular-mechanisms-and-current-evidence}
}